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Tricycloalternarene Analogs from a Symbiotic Fungus Aspergillus sp. D and Their Antimicrobial and Cytotoxic Effects.

ABSTRACT: Bioassay-guided fractionation of the crude extract of fermentation broth of one symbiotic strain Aspergillus sp. D from the coastal plant Edgeworthia chrysantha Lindl. led to isolation of one new meroterpenoid, tricycloalternarene 14b (1), together with four known analogs (2-5), tricycloalternarenes 2b (2), 3a (3), 3b (4), and ACTG-toxin F (5). Their chemical structures were unambiguously established on the basis of NMR, mass spectrometry, and optical rotation data analysis, as well as by comparison with literature data. Biological assays indicated that compound 2 exhibited potent in vitro cytotoxicity against human lung adenocarcinoma A549 cell line with an IC50 value of 2.91 ?M, and compound 5 had a moderate inhibitory effect on Candida albicans, with an MIC value of 15.63 ?M. The results indicated that this symbiotic strain D is an important producer of tricycloalternarene derivatives, with potential therapeutic application in treatment of cancer and pathogen infection.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC6017176 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Tricycloalternarene Analogs from a Symbiotic Fungus Aspergillus sp. D and Their Antimicrobial and Cytotoxic Effects.

Zhang Huawei H   Zhao Ziping Z   Chen Jianwei J   Bai Xuelian X   Wang Hong H  

Molecules (Basel, Switzerland) 20180409 4

Bioassay-guided fractionation of the crude extract of fermentation broth of one symbiotic strain <i>Aspergillus</i> sp. D from the coastal plant <i>Edgeworthia chrysantha</i> Lindl. led to isolation of one new meroterpenoid, tricycloalternarene 14b (<b>1</b>), together with four known analogs (<b>2</b>-<b>5</b>), tricycloalternarenes 2b (<b>2</b>), 3a (<b>3</b>), 3b (<b>4</b>), and ACTG-toxin F (<b>5</b>). Their chemical structures were unambiguously established on the basis of NMR, mass spectro  ...[more]

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