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Isoform selectivity of harmine-conjugated 1,2,3-triazoles against human monoamine oxidase.

ABSTRACT: AIM:There is little information available on the monoamine oxidase isoform selectivity of N-alkyl harmine analogs, which exhibit a myriad of activities including MAO-A, DYRK1A and cytotoxicity to several select cancer cell lines. RESULTS:Compounds 3e and 4c exhibited an IC50 of 0.83 ± 0.03 and 0.43 ± 0.002 ?M against MAO-A and an IC50 of 0.26 ± 0.04 and 0.36 ± 0.001 ?M against MAO-B, respectively. Molecular docking studies revealed ?-? interactions between the synthesized molecules and aromatic amino acid residues. Conclusion & future perspective: The current study delineates the structural requirements for MAO-A selectivity and such information may be helpful in designing selective analogs for kinase, DYRK1A and harmine-based cytotoxics without apparent MAO enzyme inhibition.

SUBMITTER: Haider S

PROVIDER: S-EPMC6021913 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Isoform selectivity of harmine-conjugated 1,2,3-triazoles against human monoamine oxidase.

Haider Saqlain S Alhusban Manal M Chaurasiya Narayan D ND Tekwani Babu L BL Chittiboyina Amar G AG Khan Ikhlas A IA

Future medicinal chemistry 20180523 12

<h4>Aim</h4>There is little information available on the monoamine oxidase isoform selectivity of N-alkyl harmine analogs, which exhibit a myriad of activities including MAO-A, DYRK1A and cytotoxicity to several select cancer cell lines.<h4>Results</h4>Compounds 3e and 4c exhibited an IC<sub>50</sub> of 0.83 ± 0.03 and 0.43 ± 0.002 μM against MAO-A and an IC<sub>50</sub> of 0.26 ± 0.04 and 0.36 ± 0.001 μM against MAO-B, respectively. Molecular docking studies revealed π-π interactions between th ...[more]

PMID: 29788780

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