Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer.
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ABSTRACT:
SUBMITTER: Yan J
PROVIDER: S-EPMC6028064 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer.
Yan Juming J Smyth Mark J MJ Teng Michele W L MWL
Cold Spring Harbor perspectives in biology 20180702 7
The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity. In this review, we discuss the role IL-12 and IL-23 plays in tumor biology from preclinical and clinical data. In particular, we discuss the mechanism by which IL-23 promotes tumor growth and metastases and how the IL-12/IL-23 axis of inflammation can be targeted for cancer therapy. ...[more]
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