Ontology highlight
ABSTRACT:
SUBMITTER: Kauffman WB
PROVIDER: S-EPMC6028423 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Kauffman W Berkeley WB Guha Shantanu S Wimley William C WC
Nature communications 20180702 1
Peptides and analogs such as peptide nucleic acids (PNA) are promising tools and therapeutics, but the cell membrane remains a barrier to intracellular targets. Conjugation to classical cell penetrating peptides (CPPs) such as pTat<sub>48-60</sub> (tat) and pAntp<sub>43-68</sub> (penetratin) facilitates delivery; however, efficiencies are low. Lack of explicit design principles hinders rational improvement. Here, we use synthetic molecular evolution (SME) to identify gain-of-function CPPs with d ...[more]