Ontology highlight
ABSTRACT:
SUBMITTER: Maras JS
PROVIDER: S-EPMC6035223 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Maras Jaswinder Singh JS Das Sukanta S Sharma Sachin S Sukriti Sukriti S Kumar Jitendra J Vyas Ashish Kumar AK Kumar Dhananjay D Bhat Adil A Yadav Gaurav G Choudhary Manish Chandra MC Sharma Shvetank S Kumar Guresh G Bihari Chhagan C Trehanpati Nirupma N Maiwall Rakhi R Sarin Shiv Kumar SK
Scientific reports 20180706 1
Severe alcoholic hepatitis (SAH) is associated with iron accumulation in hepatocytes/macrophages. This possibly correlates with inflammation and stress but the exact mechanism still remains obscure. To understand the role of iron and the mechanisms of systemic iron-overload, a transcriptomic study of liver and Peripheral Blood -Mononuclear-Cells (PBMCs) was undertaken in SAH patients, with and without hepatic iron-overload. Our results show that iron-overload in hepatocytes/macrophages is due to ...[more]