Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy.
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ABSTRACT:
SUBMITTER: Fisel P
PROVIDER: S-EPMC6039204 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
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Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy.
Fisel Pascale P Schaeffeler Elke E Schwab Matthias M
Clinical and translational science 20180416 4
The solute carrier (SLC) SLC16 gene family comprises 14 members and encodes for monocarboxylate transporters (MCTs), which mediate the absorption and distribution of monocarboxylic compounds across plasma membranes. As the knowledge about their physiological function, activity, and regulation increases, their involvement and contribution to cancer and other diseases become increasingly evident. Moreover, promising opportunities for therapeutic interventions by directly targeting their endogenous ...[more]
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