Ontology highlight
ABSTRACT:
SUBMITTER: Dykes IM
PROVIDER: S-EPMC6041270 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Dykes Iain M IM Szumska Dorota D Kuncheria Linta L Puliyadi Rathi R Chen Chiann-Mun CM Papanayotou Costis C Lockstone Helen H Dubourg Christèle C David Véronique V Schneider Jurgen E JE Keane Thomas M TM Adams David J DJ Brown Steve D M SDM Mercier Sandra S Odent Sylvie S Collignon Jérôme J Bhattacharya Shoumo S
Scientific reports 20180711 1
ZIC2 mutation is known to cause holoprosencephaly (HPE). A subset of ZIC2 HPE probands harbour cardiovascular and visceral anomalies suggestive of laterality defects. 3D-imaging of novel mouse Zic2 mutants uncovers, in addition to HPE, laterality defects in lungs, heart, vasculature and viscera. A strong bias towards right isomerism indicates a failure to establish left identity in the lateral plate mesoderm (LPM), a phenotype that cannot be explained simply by the defective ciliogenesis previou ...[more]