Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC6041281 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Li Linxin L Friedrichsen Hans J HJ Andrews Sarah S Picaud Sarah S Volpon Laurent L Ngeow Kaochin K Berridge Georgina G Fischer Roman R Borden Katherine L B KLB Filippakopoulos Panagis P Goding Colin R CR
Nature communications 20180711 1
How cells coordinate the response to fluctuating carbon and nitrogen availability required to maintain effective homeostasis is a key issue. Amino acid limitation that inactivates mTORC1 promotes de-phosphorylation and nuclear translocation of Transcription Factor EB (TFEB), a key transcriptional regulator of lysosome biogenesis and autophagy that is deregulated in cancer and neurodegeneration. Beyond its cytoplasmic sequestration, how TFEB phosphorylation regulates its nuclear-cytoplasmic shutt ...[more]