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Structural aspects of chaperone-mediated peptide loading in the MHC-I antigen presentation pathway.

ABSTRACT: Recognition of foreign and dysregulated antigens by the cellular innate and adaptive immune systems is in large part dependent on the cell surface display of peptide/MHC (pMHC) complexes. The formation of such complexes requires the generation of antigenic peptides, proper folding of MHC molecules, loading of peptides onto MHC molecules, glycosylation, and transport to the plasma membrane. This complex series of biosynthetic, biochemical, and cell biological reactions is known as "antigen processing and presentation". Here, we summarize recent work, focused on the structural and functional characterization of the key MHC-I-dedicated chaperones, tapasin, and TAPBPR. The mechanisms reflect the ability of conformationally flexible molecules to adapt to their ligands, and are comparable to similar processes that are exploited in peptide antigen loading in the MHC-II pathway.

SUBMITTER: Natarajan K

PROVIDER: S-EPMC6859838 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Structural aspects of chaperone-mediated peptide loading in the MHC-I antigen presentation pathway.

Natarajan Kannan K Jiang Jiansheng J Margulies David H DH

Critical reviews in biochemistry and molecular biology 20190401 2

Recognition of foreign and dysregulated antigens by the cellular innate and adaptive immune systems is in large part dependent on the cell surface display of peptide/MHC (pMHC) complexes. The formation of such complexes requires the generation of antigenic peptides, proper folding of MHC molecules, loading of peptides onto MHC molecules, glycosylation, and transport to the plasma membrane. This complex series of biosynthetic, biochemical, and cell biological reactions is known as "antigen proces ...[more]

PMID: 31084439

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