Ontology highlight
ABSTRACT:
SUBMITTER: Imai H
PROVIDER: S-EPMC6821745 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Imai Hiroko H Yoshimura Kentaro K Miyamoto Yoichi Y Sasa Kiyohito K Sugano Marika M Chatani Masahiro M Takami Masamichi M Yamamoto Matsuo M Kamijo Ryutaro R
Scientific reports 20191030 1
Monocarboxylate transporters (MCTs) provide transmembrane transport of monocarboxylates such as lactate and pyruvate. The present results showed that α-cyano-4-hydroxycinnamic acid (CHC), an inhibitor of MCTs, promoted osteoclast differentiation from macrophages at lower concentrations (0.1-0.3 mM) and suppressed that at a higher concentration (1.0 mM). On the other hand, CHC reduced the number of mature osteoclasts on the surface of dentin in a concentration-dependent manner. Additionally, macr ...[more]