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Pericytes in the Premetastatic Niche.

ABSTRACT: The premetastatic niche formed by primary tumor-derived molecules contributes to fixation of cancer metastasis. The design of efficient therapies is limited by the current lack of knowledge about the details of cellular and molecular mechanisms involved in the premetastatic niche formation. Recently, the role of pericytes in the premetastatic niche formation and lung metastatic tropism was explored by using state-of-the-art techniques, including in vivo lineage-tracing and mice with pericyte-specific KLF4 deletion. Strikingly, genetic inactivation of KLF4 in pericytes inhibits pulmonary pericyte expansion and decreases metastasis in the lung. Here, we summarize and evaluate recent advances in the understanding of pericyte contribution to premetastatic niche formation. Cancer Res; 78(11); 2779-86. ©2018 AACR.

SUBMITTER: Paiva AE

PROVIDER: S-EPMC6044472 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Pericytes in the Premetastatic Niche.

Paiva Ana E AE Lousado Luiza L Guerra Daniel A P DAP Azevedo Patrick O PO Sena Isadora F G IFG Andreotti Julia P JP Santos Gabryella S P GSP Gonçalves Ricardo R Mintz Akiva A Birbrair Alexander A

Cancer research 20180522 11

The premetastatic niche formed by primary tumor-derived molecules contributes to fixation of cancer metastasis. The design of efficient therapies is limited by the current lack of knowledge about the details of cellular and molecular mechanisms involved in the premetastatic niche formation. Recently, the role of pericytes in the premetastatic niche formation and lung metastatic tropism was explored by using state-of-the-art techniques, including <i>in vivo</i> lineage-tracing and mice with peric ...[more]

PMID: 29789421

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