Ontology highlight
ABSTRACT:
SUBMITTER: Huang YL
PROVIDER: S-EPMC7541088 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Huang Yen-Lin YL Liang Ching-Yeu CY Ritz Danilo D Coelho Ricardo R Septiadi Dedy D Estermann Manuela M Cumin Cécile C Rimmer Natalie N Schötzau Andreas A Núñez López Mónica M Fedier André A Konantz Martina M Vlajnic Tatjana T Calabrese Diego D Lengerke Claudia C David Leonor L Rothen-Rutishauser Barbara B Jacob Francis F Heinzelmann-Schwarz Viola V
eLife 20201007
The extracellular matrix (ECM) plays critical roles in tumor progression and metastasis. However, the contribution of ECM proteins to early metastatic onset in the peritoneal cavity remains unexplored. Here, we suggest a new route of metastasis through the interaction of integrin alpha 2 (ITGA2) with collagens enriched in the tumor coinciding with poor outcome in patients with ovarian cancer. Using multiple gene-edited cell lines and patient-derived samples, we demonstrate that ITGA2 triggers ca ...[more]