Dataset Information

Zinc(II)-Tetradentate-Coordinated Probe with Aggregation-Induced Emission Characteristics for Selective Imaging and Photoinactivation of Bacteria.

ABSTRACT: The emergence of drug-resistant bacterial pathogens highlights an urgent need for new therapeutic options. Photodynamic therapy (PDT) has emerged as a potential alternative to antibiotics to kill bacteria, which has been used in clinical settings. PDT employs photosensitizers (PSs), light, and oxygen to kill bacteria by generating highly reactive oxygen species (ROS). PDT can target both external and internal structures of bacteria, which does not really require the PSs to enter bacteria. Therefore, bacteria can hardly develop resistance to PDT. However, most of the PSs reported so far are hydrophobic and tend to form aggregates when they interact with bacteria. The aggregation could cause fluorescence quenching and reduce ROS generation, which generally compromises the effects of both imaging and therapy. In this contribution, we report on a Zn(II)-tetradentate-coordinated red-emissive probe with aggregation-induced emission characterization. The probe could selectively image bacteria over mammalian cells. Moreover, the probe shows potent phototoxicity to both Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Bacillus subtilis).

SUBMITTER: Feng G

PROVIDER: S-EPMC6044760 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Zinc(II)-Tetradentate-Coordinated Probe with Aggregation-Induced Emission Characteristics for Selective Imaging and Photoinactivation of Bacteria.

Feng Guangxue G Zhang Chong-Jing CJ Lu Xianmao X Liu Bin B

ACS omega 20170214 2

The emergence of drug-resistant bacterial pathogens highlights an urgent need for new therapeutic options. Photodynamic therapy (PDT) has emerged as a potential alternative to antibiotics to kill bacteria, which has been used in clinical settings. PDT employs photosensitizers (PSs), light, and oxygen to kill bacteria by generating highly reactive oxygen species (ROS). PDT can target both external and internal structures of bacteria, which does not really require the PSs to enter bacteria. Theref ...[more]

PMID: 30023611

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Project description:Positional isomers of zinc-nitrobenzoate complexes possessing pyridine -3-(or-4-) carboxamide are used for a comparative theoretical and experimental study to understand their utility as model complexes to understand the role of metal-to-ligand charge transfer in aggregation-induced emission (AIE). Among the five different model zinc complexes, four of them are non-ionic, and one is an ionic complex. The frontier molecular energy levels of different combinations of the positional isomeric complexes and the absorption maximum were ascertained by density functional theory calculations. The PolyQ value obtained from solid samples of each complex is different. Shifts in the emissions to higher wavelengths than the expected emission for the S1 to S0 transition were observed due to aggregations. The highest value of PolyQ among the complexes was 13.56% observed for emission at 439 nm (λex = 350) of the non-ionic complex, namely, (di-aqua)bis(pyridine-3-carboxamide)di(2-nitrobenzoato)zinc(II) monohydrate. Close resemblance in emission lifetime decay profiles of the solid samples of those complexes and the respective solutions of those complexes in dimethyl sulfoxide with or without water showed a common trend, suggesting aggregation-induced emission in each case. Aggregation-induced emission caused by adding water in dimethyl sulfoxide solution of each complex showed an initial increase without a shift in the emission wavelength followed by a quenching with a shift of the respective emission peak to a short wavelength. Dynamic light scattering studies showed an increase in the average particle sizes upon an increase in the concentration of water. This indicated initial participation of water molecules to form aggregates with the complexes, favoring an increase in the AIE intensity. Aggregation of each complex changes with the concentration of water, and an increase in the concentration of water beyond a characteristic limit causes lowering of the emission intensity to the short wavelength.

Dataset Information

Zinc(II)-Tetradentate-Coordinated Probe with Aggregation-Induced Emission Characteristics for Selective Imaging and Photoinactivation of Bacteria.

Publications

Zinc(II)-Tetradentate-Coordinated Probe with Aggregation-Induced Emission Characteristics for Selective Imaging and Photoinactivation of Bacteria.

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