Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC6045570 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Li Min M Xu Xiaohua X Chang Chou-Wei CW Zheng Li L Shen Binghui B Liu Yilun Y
Nature communications 20180713 1
During DNA synthesis, DNA replication and transcription machinery can collide, and the replication fork may temporarily dislodge RNA polymerase II (RNAPII) to resolve the transcription-replication conflict (TRC), a major source of endogenous DNA double-strand breaks (DSBs) and common fragile site (CFS) instability. However, the mechanism of TRC resolution remains unclear. Here, we show that conjugation of SUMO2, but not SUMO1 or SUMO3, to the essential replication factor PCNA is induced on trans ...[more]