Differentially Methylated Genes in Saliva are linked to Childhood Stress.
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ABSTRACT:
SUBMITTER: Papale LA
PROVIDER: S-EPMC6050255 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Differentially Methylated Genes in Saliva are linked to Childhood Stress.
Papale Ligia A LA Seltzer Leslie J LJ Madrid Andy A Pollak Seth D SD Alisch Reid S RS
Scientific reports 20180717 1
Chronic and severe stress exposure in early childhood is associated with the development of psychiatric disorders. Yet, the molecular mechanisms underlying this relationship remain poorly understood. Here, we profile molecular marks (DNA methylation and gene expression) throughout the human genome to determine the associations between childhood stress exposure and gene regulation. To do so, we collected saliva tissue from prepubertal girls (mean age 10.9 ± 1.26 years) who had experienced differe ...[more]
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