Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC6050576 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Chemical science 20180612 26
A copper(i)-catalyzed dearomative borylation of <i>N</i>-alkoxycarbonyl protected indole-3-carboxylates has been developed. The boron addition in this reaction occurred regioselectively at the 2-position of indoles followed by diastereoselective protonation, affording the corresponding stable cyclic chiral α-amino boronates (2-borylindolines) in moderate to good yields with excellent diastereo- and enantioselectivities. The product <b>2c</b> could be used as a versatile precursor to undergo subs ...[more]