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Recovery of Cardiac Remodeling and Dysmetabolism by Pancreatic Islet Injury Improvement in Diabetic Rats after Yacon Leaf Extract Treatment.

ABSTRACT: Yacon (Smallanthus sonchifolius) is a native Andean plant rich in phenolic compounds, and its effects on dysmetabolism and cardiomyopathy in diabetic rats was evaluated. The rats (10/group) were allocated as follows: C, controls; C?+?Y, controls treated with Yacon leaf extract (YLE); DM, diabetic controls; and DM?+?Y, diabetic rats treated with YLE. Type 1 diabetes (T1DM) was induced by the administration of streptozotocin (STZ; 40?mg-1/kg body weight, single dose, i.p.), and treated groups received 100?mg/kg body weight YLE daily via gavage for 30?d. The YLE group shows an improvement in dysmetabolism and cardiomyopathy in the diabetic condition (DM versus DM?+?Y) promoting a significant reduction of glycemia by 63.39%, an increase in insulin concentration by 49.30%, and a decrease in serum triacylglycerol and fatty acid contents by 0.39- and 0.43-fold, respectively, by ameliorating the pancreatic islet injury, as well as increasing the activity of the antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) and decreasing the fibrosis and cellular disorganization in cardiac tissue. The apparent benefits of YLE seem to be mediated by ameliorating dysmetabolism and oxidative stress in pancreatic and cardiac tissues.

SUBMITTER: Dos Santos KC

PROVIDER: S-EPMC6051012 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Recovery of Cardiac Remodeling and Dysmetabolism by Pancreatic Islet Injury Improvement in Diabetic Rats after Yacon Leaf Extract Treatment.

Dos Santos Klinsmann Carolo KC Cury Sarah Santiloni SS Ferraz Ana Paula Costa Rodrigues APCR Corrente José Eduardo JE Gonçalves Bianca Mariani BM de Araújo Machado Luiz Henrique LH Carvalho Robson Francisco RF de Melo Stevanato Nakamune Ana Cláudia AC Fabro Alexandre Todorovic AT Freire Paula Paccielli PP Corrêa Camila Renata CR

Oxidative medicine and cellular longevity 20180410

Yacon (<i>Smallanthus sonchifolius</i>) is a native Andean plant rich in phenolic compounds, and its effects on dysmetabolism and cardiomyopathy in diabetic rats was evaluated. The rats (10/group) were allocated as follows: C, controls; C + Y, controls treated with Yacon leaf extract (YLE); DM, diabetic controls; and DM + Y, diabetic rats treated with YLE. Type 1 diabetes (T1DM) was induced by the administration of streptozotocin (STZ; 40 mg<sup>-1</sup>/kg body weight, single dose, i.p.), and t ...[more]

PMID: 30057670

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Dataset Information

Recovery of Cardiac Remodeling and Dysmetabolism by Pancreatic Islet Injury Improvement in Diabetic Rats after Yacon Leaf Extract Treatment.

Publications

Recovery of Cardiac Remodeling and Dysmetabolism by Pancreatic Islet Injury Improvement in Diabetic Rats after Yacon Leaf Extract Treatment.

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