Ontology highlight
ABSTRACT:
SUBMITTER: Johnstone AD
PROVIDER: S-EPMC6051587 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Johnstone Aaron D AD Hallett Robin M RM de Léon Andrés A Carturan Bruno B Gibon Julien J Barker Philip A PA
PloS one 20180718 7
Axons normally degenerate during development of the mammalian nervous system, but dysregulation of the same genetically-encoded destructive cellular machinery can destroy crucial structures during adult neurodegenerative diseases. Nerve growth factor (NGF) withdrawal from dorsal root ganglia (DRG) axons is a well-established in vitro experimental model for biochemical and cell biological studies of developmental degeneration. Definitive methods for measuring axon degeneration have been lacking a ...[more]