Ontology highlight
ABSTRACT:
SUBMITTER: Zhu SY
PROVIDER: S-EPMC6052394 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Zhu Si-Yuan SY Zhuang Jing-Shen JS Wu Qian Q Liu Zhong-Yuan ZY Liao Cong-Rui CR Luo Shi-Gan SG Chen Jian-Ting JT Zhong Zhao-Ming ZM
Aging cell 20180416 4
Osteoblast apoptosis contributes to age-related bone loss. Advanced oxidation protein products (AOPPs) are recognized as the markers of oxidative stress and potent inducers of apoptosis. We have demonstrated that AOPP accumulation was correlated with age-related bone loss. However, the effect of AOPPs on the osteoblast apoptosis still remains unknown. Exposure of osteoblastic MC3T3-E1 cells to AOPPs caused the excessive generation of reactive oxygen species (ROS) by activating nicotinamide adeni ...[more]