Ontology highlight
ABSTRACT:
SUBMITTER: Hoshii T
PROVIDER: S-EPMC6052445 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Cell 20180201 5
MLL/SET methyltransferases catalyze methylation of histone 3 lysine 4 and play critical roles in development and cancer. We assessed MLL/SET proteins and found that SETD1A is required for survival of acute myeloid leukemia (AML) cells. Mutagenesis studies and CRISPR-Cas9 domain screening show the enzymatic SET domain is not necessary for AML cell survival but that a newly identified region termed the "FLOS" (functional location on SETD1A) domain is indispensable. FLOS disruption suppresses DNA d ...[more]