Ontology highlight
ABSTRACT:
SUBMITTER: van der Peet PL
PROVIDER: S-EPMC6053635 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
van der Peet Phillip L PL Gunawan Christian C Abdul-Ridha Alaa A Ma Sherie S Scott Daniel J DJ Gundlach Andrew L AL Bathgate Ross A D RAD White Jonathan M JM Williams Spencer J SJ
MethodsX 20180323
Chemogenetics uses engineered proteins that are controlled by small molecule actuators, allowing <i>in vivo</i> functional studies of proteins with temporal and dose control, and include Designer Receptors Exclusively Activated by Designer Drugs (DREADDs). One major class of DREADDs are mutated muscarinic receptors that are unresponsive to acetylcholine, and are activated by administration of clozapine <i>N</i>-oxide (CNO). However, CNO is available in only small amounts and large scale studies ...[more]