Ontology highlight
ABSTRACT:
SUBMITTER: Knauss JL
PROVIDER: S-EPMC6056501 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Knauss Jennifer L JL Miao Nan N Kim Seung-Nam SN Nie Yanzhen Y Shi Yuelin Y Wu Tao T Pinto Hugo Borges HB Donohoe Mary E ME Sun Tao T
Cell death & disease 20180723 8
Long noncoding RNAs (lncRNAs) are emerging as key regulators of crucial cellular processes. However, the molecular mechanisms of many lncRNA functions remain uncharacterized. Sox2ot is an evolutionarily conserved lncRNA that transcriptionally overlaps the pluripotency gene Sox2, which maintains the stemness of embryonic stem cells and tissue-specific stem cells. Here, we show that Sox2ot is expressed in the developing mouse cerebral cortex, where it represses neural progenitor (NP) proliferation ...[more]