Ontology highlight
ABSTRACT:
SUBMITTER: Rai PK
PROVIDER: S-EPMC6056713 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Rai Pavandeep K PK Craven Lyndsey L Hoogewijs Kurt K Russell Oliver M OM Lightowlers Robert N RN
Essays in biochemistry 20180720 3
Mitochondrial DNA (mtDNA) is a multi-copy genome whose cell copy number varies depending on tissue type. Mutations in mtDNA can cause a wide spectrum of diseases. Mutated mtDNA is often found as a subset of the total mtDNA population in a cell or tissue, a situation known as heteroplasmy. As mitochondrial dysfunction only presents after a certain level of heteroplasmy has been acquired, ways to artificially reduce or replace the mutated species have been attempted. This review addresses recent a ...[more]