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A copper-mediated reverse aromatic Finkelstein reaction in ionic liquid.

ABSTRACT: We have developed a general method for reverse aromatic Finkelstein reactions. Good reaction yields were obtained when aryl iodides or aryl bromides were treated with copper halide salts as promoters in a 1-butyl-3-methylimidazolium bromide ([BMIM]Br) ionic liquid (IL) solvent at 140?°C for 8?h. Preliminary investigation supported that the copper salts were also the halide sources in halogen exchange reactions. The optimized conditions are applicable to a variety of substrates and have excellent functional group tolerance. Additionally, the [BMIM]Br solvent showed good stability for at least 10 consecutive runs. Results indicated that the [BMIM]Br solvent was recyclable for reverse aromatic Finkelstein reactions.

SUBMITTER: Nguyen ATH

PROVIDER: S-EPMC6057234 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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A copper-mediated reverse aromatic Finkelstein reaction in ionic liquid.

Nguyen Anh T H ATH Nguyen Dat P DP Phan Ngan T K NTK Lam Dung T T DTT Phan Nam T S NTS Truong Thanh T

Journal of advanced research 20171229

We have developed a general method for reverse aromatic Finkelstein reactions. Good reaction yields were obtained when aryl iodides or aryl bromides were treated with copper halide salts as promoters in a 1-butyl-3-methylimidazolium bromide ([BMIM]Br) ionic liquid (IL) solvent at 140 °C for 8 h. Preliminary investigation supported that the copper salts were also the halide sources in halogen exchange reactions. The optimized conditions are applicable to a variety of substrates and have excellent ...[more]

PMID: 30046471

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