Drug screening for human genetic diseases using iPSC models.
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ABSTRACT:
SUBMITTER: Elitt MS
PROVIDER: S-EPMC6061782 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Drug screening for human genetic diseases using iPSC models.
Elitt Matthew S MS Barbar Lilianne L Tesar Paul J PJ
Human molecular genetics 20180801 R2
Induced pluripotent stem cells (iPSCs) enable the generation of previously unattainable, scalable quantities of disease-relevant tissues from patients suffering from essentially any genetic disorder. This cellular material has proven instrumental for drug screening efforts on these disorders, and has facilitated the identification of novel therapeutics for patients. Here we will review the foundational technologies that have enabled iPSCs, the power and limitations of iPSC-based compound screens ...[more]
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