Natural [4 + 2]-Cyclases.
Ontology highlight
ABSTRACT:
SUBMITTER: Jeon BS
PROVIDER: S-EPMC6063532 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Natural [4 + 2]-Cyclases.
Jeon Byung-Sun BS Wang Shao-An SA Ruszczycky Mark W MW Liu Hung-Wen HW
Chemical reviews 20161201 8
[4 + 2]-Cycloadditions are increasingly being recognized in the biosynthetic pathways of many structurally complex natural products. A relatively small collection of enzymes from these pathways have been demonstrated to increase rates of cyclization and impose stereochemical constraints on the reactions. While mechanistic investigation of these enzymes is just beginning, recent studies have provided new insights with implications for understanding their biosynthetic roles, mechanisms of catalysi ...[more]
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