Ontology highlight
ABSTRACT:
SUBMITTER: Tutunea-Fatan E
PROVIDER: S-EPMC6065385 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Tutunea-Fatan Elena E Abd-Elrahman Khaled S KS Thibodeau Jean-Francois JF Holterman Chet E CE Holleran Brian J BJ Leduc Richard R Kennedy Christopher R J CRJ Gros Robert R Ferguson Stephen S G SSG
Scientific reports 20180730 1
The renin-angiotensin system regulates blood pressure and fluid balance in the body primarily via angiotensin receptor 1 (AT1R). Renal AT1R was found to be primarily responsible for Ang II-mediated hypertension. G protein-coupled receptor kinase 2 (GRK2) modulates AT1R desensitization and increased GRK2 protein expression is reported in hypertensive patients. However, the consequences of GRK2 inhibition on kidney functions remain unknown. We employed shGRK2 knockdown mice (shGRK2 mice) to test t ...[more]