Ontology highlight
ABSTRACT:
SUBMITTER: Aoki ST
PROVIDER: S-EPMC6066285 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Aoki Scott T ST Porter Douglas F DF Prasad Aman A Wickens Marvin M Bingman Craig A CA Kimble Judith J
Cell reports 20180601 13
FOG-3 is a master regulator of sperm fate in Caenorhabditis elegans and homologous to Tob/BTG proteins, which in mammals are monomeric adaptors that recruit enzymes to RNA binding proteins. Here, we determine the FOG-3 crystal structure and in vitro demonstrate that FOG-3 forms dimers that can multimerize. The FOG-3 multimeric structure has a basic surface potential, suggestive of binding nucleic acid. Consistent with that prediction, FOG-3 binds directly to nearly 1,000 RNAs in nematode spermat ...[more]