Ontology highlight
ABSTRACT:
SUBMITTER: Mangale VS
PROVIDER: S-EPMC2494603 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Mangale Vishakha S VS Hirokawa Karla E KE Satyaki Prasad R V PR Gokulchandran Nandini N Chikbire Satyadeep S Subramanian Lakshmi L Shetty Ashwin S AS Martynoga Ben B Paul Jolly J Mai Mark V MV Li Yuqing Y Flanagan Lisa A LA Tole Shubha S Monuki Edwin S ES
Science (New York, N.Y.) 20080101 5861
The earliest step in creating the cerebral cortex is the specification of neuroepithelium to a cortical fate. Using mouse genetic mosaics and timed inactivations, we demonstrated that Lhx2 acts as a classic selector gene and essential intrinsic determinant of cortical identity. Lhx2 selector activity is restricted to an early critical period when stem cells comprise the cortical neuroepithelium, where it acts cell-autonomously to specify cortical identity and suppress alternative fates in a spat ...[more]