Ontology highlight
ABSTRACT:
SUBMITTER: Gutierrez-Martinez P
PROVIDER: S-EPMC6067675 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Gutierrez-Martinez Paula P Hogdal Leah L Nagai Manavi M Kruta Miriama M Singh Rumani R Sarosiek Kristopher K Nussenzweig Andre A Beerman Isabel I Letai Anthony A Rossi Derrick J DJ
Nature cell biology 20180312 4
Ageing of haematopoietic stem cells (HSCs) contributes to deficits in the aged haematopoietic system. HSC decline is driven in part by DNA damage accumulation; yet, how ageing impacts the acute DNA damage response (DDR) of HSCs is poorly understood. We show that old HSCs exhibit diminished ATM activity and attenuated DDR, leading to elevated clonal survival in response to a range of genotoxins that was underwritten by diminished apoptotic priming. Distinct HSC subsets exhibited ageing-dependent ...[more]