Linear motifs confer functional diversity onto splice variants.
Ontology highlight
ABSTRACT:
SUBMITTER: Weatheritt RJ
PROVIDER: S-EPMC3424572 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Publications
Linear motifs confer functional diversity onto splice variants.
Weatheritt Robert J RJ Davey Norman E NE Gibson Toby J TJ
Nucleic acids research 20120525 15
The pre-translational modification of messenger ribonucleic acids (mRNAs) by alternative promoter usage and alternative splicing is an important source of pleiotropy. Despite intensive efforts, our understanding of the functional implications of this dynamically created diversity is still incomplete. Using the available knowledge of interaction modules, particularly within intrinsically disordered regions (IDRs), we analysed the occurrences of protein modules within alternative exons. We find th ...[more]
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