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Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus.

ABSTRACT: In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the culture broth and the mycelium in the culture medium, by the addition of l-tryptophan and l-phenylalanine. Their chemical structures were established by one dimensional (1D), two dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) data. Among them, scequinadoline A (5) exhibited significant inhibitory activity against dengue virus serotype 2 production by standard plaque assay, equivalent to the positive control andrographlide. Scequinadoline A (5) possesses the potential for further development as a dengue virus inhibitor.

SUBMITTER: Wu DL 

PROVIDER: S-EPMC6071211 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Polyketides and Alkaloids from the Marine-Derived Fungus <i>Dichotomomyces cejpii</i> F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus.

Wu Dong-Lan DL   Li Hou-Jin HJ   Smith Duncan R DR   Jaratsittisin Janejira J   Xia-Ke-Er Xia-Fu-Kai-Ti XF   Ma Wen-Zhe WZ   Guo Yong-Wei YW   Dong Jun J   Shen Juan J   Yang De-Po DP   Lan Wen-Jian WJ  

Marine drugs 20180706 7

In our continuous chemical investigation on the marine-derived fungus <i>Dichotomomyces cejpii</i> F31-1, two new polyketides dichocetides B-C (<b>1</b>, <b>2</b>), two new alkaloids dichotomocejs E-F (<b>3</b>, <b>4</b>), and three known fumiquinozalines: scequinadoline A (<b>5</b>), quinadoline A (<b>6</b>), and scequinadoline E (<b>7</b>) were discovered from the culture broth and the mycelium in the culture medium, by the addition of l-tryptophan and l-phenylalanine. Their chemical structure  ...[more]

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