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New Polyketides from the Marine-Derived Fungus Letendraea sp. 5XNZ4-2.

ABSTRACT: Marine-derived fungi have been reported to have great potential to produce structurally unique metabolites. Our investigation on secondary metabolites from marine-derived fungi resulted in the isolation of seven new polyketides (phomopsiketones D-G (1-4) and letendronols A-C (5-7)) as well as one known xylarinol (8) in the cultural broth of Letendraea sp. Their structures and absolute configurations were elucidated using a set of spectroscopic and chemical methods, including HRESIMS, NMR, single-crystal X-ray diffraction, ECD calculation, and a modified version of Mosher's method. Compound 2 showed weak inhibition against nitric oxide production in lipopolysaccaride-activated macrophages with an IC50 value of 86 ?M.

SUBMITTER: Xu Y

PROVIDER: S-EPMC7024145 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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New Polyketides from the Marine-Derived Fungus Letendraea sp. 5XNZ4-2.

Xu Yan Y Huang Ruibao R Liu Hongwei H Yan Tingting T Ding Wanjing W Jiang Yongjun Y Wang Pinmei P Zheng Daoqiong D Xu Jinzhong J

Marine drugs 20191224 1

Marine-derived fungi have been reported to have great potential to produce structurally unique metabolites. Our investigation on secondary metabolites from marine-derived fungi resulted in the isolation of seven new polyketides (phomopsiketones D-G (1-4) and letendronols A-C (5-7)) as well as one known xylarinol (8) in the cultural broth of Letendraea sp. Their structures and absolute configurations were elucidated using a set of spectroscopic and chemic ...[more]

PMID: 31878313

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