Ontology highlight
ABSTRACT:
SUBMITTER: Inesta-Vaquera F
PROVIDER: S-EPMC6071836 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Inesta-Vaquera Francisco F Chaugule Viduth K VK Galloway Alison A Chandler Laurel L Rojas-Fernandez Alejandro A Weidlich Simone S Peggie Mark M Cowling Victoria H VH
Life science alliance 20180601 3
CMTR1 contributes to mRNA cap formation by methylating the first transcribed nucleotide ribose at the O-2 position. mRNA cap O-2 methylation has roles in mRNA stabilisation and translation, and self-RNA tolerance in innate immunity. We report that CMTR1 is recruited to serine-5-phosphorylated RNA Pol II C-terminal domain, early in transcription. We isolated CMTR1 in a complex with DHX15, an RNA helicase functioning in splicing and ribosome biogenesis, and characterised it as a regulator of CMTR1 ...[more]