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Efficient copper-catalyzed amination of DNA-conjugated aryl iodides under mild aqueous conditions.

ABSTRACT: Herein, we describe the development of copper-catalyzed cross-coupling of DNA-conjugated aryl iodides with aliphatic amines. This protocol leverages a novel ligand, 2-((2,6-dimethoxyphenyl)amino)-2-oxoacetic acid, to effect the transformation in aqueous DMSO, under mild conditions and in air, making it an ideal candidate for the synthesis of DNA-encoded libraries.

SUBMITTER: Ruff Y

PROVIDER: S-EPMC6072498 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Efficient copper-catalyzed amination of DNA-conjugated aryl iodides under mild aqueous conditions.

Ruff Yves Y Berst Frédéric F

MedChemComm 20180517 7

Herein, we describe the development of copper-catalyzed cross-coupling of DNA-conjugated aryl iodides with aliphatic amines. This protocol leverages a novel ligand, 2-((2,6-dimethoxyphenyl)amino)-2-oxoacetic acid, to effect the transformation in aqueous DMSO, under mild conditions and in air, making it an ideal candidate for the synthesis of DNA-encoded libraries. ...[more]

PMID: 30109007

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