Ontology highlight
ABSTRACT:
SUBMITTER: Rapacz A
PROVIDER: S-EPMC6072507 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Rapacz Anna A Waszkielewicz Anna M AM Pańczyk Katarzyna K Pytka Karolina K Koczurkiewicz Paulina P Piska Kamil K Pękala Elżbieta E Budziszewska Bogusława B Starek-Świechowicz Beata B Marona Henryk H
MedChemComm 20161111 1
New derivatives of <i>N</i>-[(phenoxy)alkyl]- and <i>N</i>-[(phenoxy)ethoxyethyl]aminoalkanols have been synthesized and evaluated for their anticonvulsant activity in maximal electroshock (MES), maximal electroshock seizure threshold (MEST), and pentylenetetrazol (PTZ) tests. Their neurotoxicity was evaluated <i>via</i> rotarod and chimney tests. The compounds exhibiting the most beneficial activity and protection indices were evaluated for analgesic activity using the formalin test for neuroge ...[more]