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Antiproliferative activity of novel isatinyl/indanyl nitrones (INs) as potential spin trapping agents of free radical intermediates.

ABSTRACT: A series of ketonitrones derived from isatin and indanone (INs) were synthesized and evaluated for their antiproliferative activities against several human cancer cell lines. Then, the antioxidant properties of these substrates were measured by the DPPH test to report their biological activity in terms of their spin trapping action. In particular, one substrate has showed very high biological and scavenging activity, probably due to the strong correlation between its spin trapping activity and structure.

SUBMITTER: Maiuolo L 

PROVIDER: S-EPMC6083742 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Antiproliferative activity of novel isatinyl/indanyl nitrones (INs) as potential spin trapping agents of free radical intermediates.

Maiuolo Loredana L   Feriotto Giordana G   Algieri Vincenzo V   Nardi Monica M   Russo Beatrice B   Di Gioia Maria Luisa ML   Furia Emilia E   Tallarida Matteo Antonio MA   Mischiati Carlo C   De Nino Antonio A  

MedChemComm 20171220 2

A series of ketonitrones derived from isatin and indanone (INs) were synthesized and evaluated for their antiproliferative activities against several human cancer cell lines. Then, the antioxidant properties of these substrates were measured by the DPPH test to report their biological activity in terms of their <i>spin trapping</i> action. In particular, one substrate has showed very high biological and scavenging activity, probably due to the strong correlation between its spin trapping activit  ...[more]

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