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Enzyme-modified non-oxidized LDL (ELDL) induces human coronary artery smooth muscle cell transformation to a migratory and osteoblast-like phenotype.


ABSTRACT: Enzyme modified non-oxidative LDL (ELDL) is effectively taken up by vascular smooth muscle cells (SMC) and mediates transition into foam cells and produces phenotypic changes in SMC function. Our data show that incubation of human coronary artery SMC (HCASMC) with low concentration of ELDL (10??g/ml) results in significantly enhanced foam cell formation compared to oxidized LDL (200??g/ml; p?

SUBMITTER: Chellan B 

PROVIDER: S-EPMC6086911 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Enzyme-modified non-oxidized LDL (ELDL) induces human coronary artery smooth muscle cell transformation to a migratory and osteoblast-like phenotype.

Chellan Bijoy B   Rojas Elizabeth E   Zhang Chunling C   Hofmann Bowman Marion A MA  

Scientific reports 20180810 1


Enzyme modified non-oxidative LDL (ELDL) is effectively taken up by vascular smooth muscle cells (SMC) and mediates transition into foam cells and produces phenotypic changes in SMC function. Our data show that incubation of human coronary artery SMC (HCASMC) with low concentration of ELDL (10 μg/ml) results in significantly enhanced foam cell formation compared to oxidized LDL (200 μg/ml; p < 0.01) or native LDL (200 μg/ml; p < 0.01). Bioinformatic network analysis identified activation of p38  ...[more]

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