Ontology highlight
ABSTRACT:
SUBMITTER: Rocca R
PROVIDER: S-EPMC6088347 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Rocca Roberta R Moraca Federica F Costa Giosuè G Talarico Carmine C Ortuso Francesco F Da Ros Silvia S Nicoletto Giulia G Sissi Claudia C Alcaro Stefano S Artese Anna A
ACS medicinal chemistry letters 20180710 8
In the last years, it has been shown that the DNA secondary structure known as G-quadruplex is also involved in the regulation of oncogenes transcription, such as <i>c-myc</i>, <i>c-Kit</i>, <i>KRAS</i>, <i>Bcl-2</i>, <i>VEGF</i>, and <i>PDGF</i>. DNA G-quadruplexes, formed in the promoter region of these proto-oncogenes, are considered alternative anticancer targets since their stabilization causes a reduction of the related oncoprotein overexpression. In this study, a structure-based virtual s ...[more]