Ontology highlight
ABSTRACT:
SUBMITTER: Kumar S
PROVIDER: S-EPMC10870291 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Kumar Satendra S Biswas Annyesha A Sudhakar Sruthi S Kumari Divya D Pradeepkumar Pushpangadan Indira PI
ACS omega 20240129 6
G-rich sequences are present across the genome and can fold to form dynamic secondary structures, namely, G-quadruplexes (G4). These structures play a pivotal role in regulating numerous biological processes including replication, transcription, and translation. Therefore, targeting these structures using molecular scaffolds is an attractive approach to modulating their functions. Herein, we report the synthesis of three estrone-based derivatives (<b>Est-1</b>, <b>Est-2</b>, and <b>Est-3</b>) wi ...[more]