Efficient support of virus-like particle assembly by the HIV-1 packaging signal.
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ABSTRACT:
SUBMITTER: Comas-Garcia M
PROVIDER: S-EPMC6092119 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Efficient support of virus-like particle assembly by the HIV-1 packaging signal.
Comas-Garcia Mauricio M Kroupa Tomas T Datta Siddhartha Ak SA Harvin Demetria P DP Hu Wei-Shau WS Rein Alan A
eLife 20180802
The principal structural component of a retrovirus particle is the Gag protein. Retroviral genomic RNAs contain a 'packaging signal' ('Ψ') and are packaged in virus particles with very high selectivity. However, if no genomic RNA is present, Gag assembles into particles containing cellular mRNA molecules. The mechanism by which genomic RNA is normally selected during virus assembly is not understood. We previously reported (<xref ref-type="bibr" rid="bib9">Comas-Garcia et al., 2017</xref>) that ...[more]
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