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Efficient and selective hydrogenation of amides to alcohols and amines using a well-defined manganese-PNN pincer complex.

ABSTRACT: Novel well-defined NNP and PNP manganese pincer complexes have been synthetized and fully characterized. The catalyst Mn-2 containing an imidazolyaminolphosphino ligand shows high activity and selectivity in the hydrogenation of a wide range of secondary and tertiary amides to the corresponding alcohols and amines, under relatively mild conditions. For the first time, more challenging substrates like primary aromatic amides including an actual herbicide can also be hydrogenated using this earth-abundant metal-based pincer catalyst.

SUBMITTER: Papa V

PROVIDER: S-EPMC6092716 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Efficient and selective hydrogenation of amides to alcohols and amines using a well-defined manganese-PNN pincer complex.

Papa Veronica V Cabrero-Antonino Jose R JR Alberico Elisabetta E Spanneberg Anke A Junge Kathrin K Junge Henrik H Beller Matthias M

Chemical science 20170308 5

Novel well-defined NNP and PNP manganese pincer complexes have been synthetized and fully characterized. The catalyst <b>Mn-2</b> containing an imidazolyaminolphosphino ligand shows high activity and selectivity in the hydrogenation of a wide range of secondary and tertiary amides to the corresponding alcohols and amines, under relatively mild conditions. For the first time, more challenging substrates like primary aromatic amides including an actual herbicide can also be hydrogenated using this ...[more]

PMID: 30155202

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