Ontology highlight
ABSTRACT:
SUBMITTER: Lloyd D
PROVIDER: S-EPMC6094935 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Lloyd Dina D Bennett Clay S CS
Chemistry (Weinheim an der Bergstrasse, Germany) 20180502 30
A next-generation reagent-controlled approach for the synthesis of 2,6-dideoxy and 2,3,6-trideoxy sugar donors in good yield and high β-selectivity is reported. The use of p-toluenesulfonyl chloride and potassium hexamethyldisilazide (KHMDS) greatly simplifies deoxy-sugar glycoside construction, and can be used for gram-scale glycosylation reactions. The development of this approach and its application to the construction of β-linked deoxy-sugar oligosaccharides are described. ...[more]