Dataset Information

Do elevated blood levels of omega-3 fatty acids modify effects of particulate air pollutants on fibrinogen?

ABSTRACT: Previously, we found short-term increases in ambient particulate matter (PM) air pollutant concentrations were associated with increased serum fibrinogen levels in patients with cardiac disease. We now studied whether high blood levels of omega-3 (?-3) fatty acids blunted this fibrinogen response to increased PM concentrations in these same patients. Plasma fibrinogen and ?-3 fatty acid levels (% of total identified fatty acids) were measured in blood samples collected from 135 patients treated at the University of Rochester Medical Center for myocardial infarction or stable ischemic heart disease requiring cardiac catheterization. Using ambient measurements of ultrafine, accumulation mode, and fine particles (PM_2.5), Delta-C, and black carbon (BC), we regressed serum fibrinogen levels against pollutant concentrations over the previous 1-96 h, using interaction terms to estimate these associations separately for those with HIGH (>?5.12%) and LOWMED serum levels of ?-3 fatty acid (??5.12%). Each 5.6 ?g/m³ increase in PM_2.5 concentration in the previous hour was associated with a 3.1% increase in fibrinogen (95% CI?=?1.5%, 4.7%) in those subjects with LOWMED total ?-3 fatty acid levels, but only a 0.9% increase (95% CI?=?-?1.5%, 3.2%) in patients with HIGH total ?-3 fatty acid levels. This same pattern was observed with fish oil-derived docosahexaenoic and eicosapentaenoic acids but not alpha-linolenic (from plant oil or seeds). A similar finding was observed with BC in the prior 24 h, but not other PM. Thus, increased blood levels of fish-based ?-3 fatty acids attenuated increases in fibrinogen associated with short-term increases in ambient PM.

SUBMITTER: Croft D

PROVIDER: S-EPMC6097058 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Do elevated blood levels of omega-3 fatty acids modify effects of particulate air pollutants on fibrinogen?

Croft Daniel D Block Robert R Cameron Scott J SJ Evans Kristin K Lowenstein Charles J CJ Ling Frederick F Zareba Wojciech W Hopke Philip K PK Utell Mark J MJ Thurston Sally W SW Thevenet-Morrison Kelly K Rich David Q DQ

Air quality, atmosphere, & health 20180603 7

Previously, we found short-term increases in ambient particulate matter (PM) air pollutant concentrations were associated with increased serum fibrinogen levels in patients with cardiac disease. We now studied whether high blood levels of omega-3 (ω-3) fatty acids blunted this fibrinogen response to increased PM concentrations in these same patients. Plasma fibrinogen and ω-3 fatty acid levels (% of total identified fatty acids) were measured in blood samples collected from 135 patients treated ...[more]

PMID: 30147809

Similar Datasets

Project description:While cardiovascular and mood benefits of dietary omega-3 fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are manifest, direct neurophysiological evidence of their effects on cortical activity is still limited. Hence we chose to examine the effects of two proprietary fish oil products with different EPA:DHA ratios (EPA-rich, high EPA:DHA; DHA-rich) on mental processing speed and visual evoked brain activity. We proposed that nonlinear multifocal visual evoked potentials (mfVEP) would be sensitive to any alteration of the neural function induced by omega-3 fatty acid supplementation, because the higher order kernel responses directly measure the degree of recovery of the neural system as a function of time following stimulation. Twenty-two healthy participants aged 18-34, with no known neurological or psychiatric disorder and not currently taking any nutritional supplementation, were recruited. A double-blind, crossover design was utilized, including a 30-day washout period, between two 30-day supplementation periods of the EPA-rich and DHA-rich diets (with order of diet randomized). Psychophysical choice reaction times and multi-focal nonlinear visual evoked potential (VEP) testing were performed at baseline (No Diet), and after each supplementation period. Following the EPA-rich supplementation, for stimulation at high luminance contrast, a significant reduction in the amplitude of the first slice of the second order VEP kernel response, previously related to activation in the magnocellular pathway, was observed. The correlations between the amplitude changes of short latency second and first order components were significantly different for the two supplementations. Significantly faster choice reaction times were observed psychophysically (compared with baseline performance) under the EPA-rich (but not DHA-rich) supplementation, while simple reaction times were not affected. The reduced nonlinearities observed under the EPA-rich diet suggest a mechanism involving more efficient neural recovery of magnocellular-like visual responses following cortical activation.

Dataset Information

Do elevated blood levels of omega-3 fatty acids modify effects of particulate air pollutants on fibrinogen?

Publications

Do elevated blood levels of omega-3 fatty acids modify effects of particulate air pollutants on fibrinogen?

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure