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Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear.

ABSTRACT: Seven compounds, including two pairs of new meroterpenoids, (+)- and (-)-gancochlearol C (1), (+)- and (-)-cochlearoid Q (3), and a new meroterpenoid gancochlearol D (2), together with four known meroterpenoids were isolated from the aqueous EtOH extract of the fruiting bodies of Ganoderma cochlear. Their structures were determined by spectroscopic data. The isolated compounds were evaluated for their cytotoxic activity against three human lung cancer cells (H1975, PC9, A549) and N-acetyltransferase inhibitory property. The results show that (+)-gancochlearol C could inhibit N-acetyltransferase with an IC₅₀ value of 5.29 ?M. In addition, ganomycin F was found to show moderate activity against the H1975 human lung cancer cell line, with an IC₅₀ value of 19.47 ?M.

SUBMITTER: Cheng LZ

PROVIDER: S-EPMC6100301 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear.

Cheng Li-Zhi LZ Qin Fu-Ying FY Ma Xiao-Chi XC Wang Shu-Mei SM Yan Yong-Ming YM Cheng Yong-Xian YX

Molecules (Basel, Switzerland) 20180720 7

Seven compounds, including two pairs of new meroterpenoids, (+)- and (-)-gancochlearol C (1), (+)- and (-)-cochlearoid Q (3), and a new meroterpenoid gancochlearol D (2), together with four known meroterpenoids were isolated from the aqueous EtOH extract of the fruiting bodies of Ganoderma cochlear. Their structures were determined by spectroscopic data. The isolated compounds were evaluated for their cytotoxic activity against three human lung cancer cells (H1975, PC ...[more]

PMID: 30037018

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