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Five New Meroterpenoids from the Fruiting Bodies of the Basidiomycete Clitocybe clavipes with Cytotoxic Activity.


ABSTRACT: Five new meroterpenoids, clavipols A-B (1-2) with a 12-membered ether ring and clavilactones G-I (3-5) having a 10-membered carbocycle connected to a hydroquinone and an ?,?-epoxy/unsaturated lactone, were obtained from the fruiting bodies of the basidiomycete Clitocybe clavipes. Their structures were determined by comprehensive analysis of their spectroscopic data, and the absolute configuration of 1 was established by quantum chemical calculations of electronic circular dichroism (ECD). All the isolated compounds (1-5) were tested for their cytotoxic activity against three human tumor cell lines (Hela, SGC-7901, and SHG-44) in vitro after treatment for 48 h. Compound 4 exhibited moderate cytotoxic activity against Hela and SGC-7901 tumor cell lines, with IC50 values of 23.5 and 14.5 µM, respectively.

SUBMITTER: Zhaocui S 

PROVIDER: S-EPMC6891274 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Five New Meroterpenoids from the Fruiting Bodies of the Basidiomycete <i>Clitocybe clavipes</i> with Cytotoxic Activity.

Zhaocui Sun S   Xudong Xu X   Hanqiao Liang L   Xinyi Xia X   Guoxu Ma M   Leiling Shi S  

Molecules (Basel, Switzerland) 20191106 22


Five new meroterpenoids, clavipols A-B (<b>1</b>-<b>2</b>) with a 12-membered ether ring and clavilactones G-I (<b>3</b>-<b>5</b>) having a 10-membered carbocycle connected to a hydroquinone and an α,β-epoxy/unsaturated lactone, were obtained from the fruiting bodies of the basidiomycete <i>Clitocybe clavipes</i>. Their structures were determined by comprehensive analysis of their spectroscopic data, and the absolute configuration of <b>1</b> was established by quantum chemical calculations of e  ...[more]

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