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Meroterpenoids from the Fungus Ganoderma sinensis and First Absolute Configuration Clarification of Zizhine H.


ABSTRACT: Five new meroterpenoids, zizhines P-S and U (1-4,7), together with two known meroterpenoids (5 and 6) were isolated from Ganoderma sinensis. Their structures including absolute configurations were assigned by using spectroscopic, computational, and chemical methods. Racemics zizhines P and Q were purified by HPLC on chiral phase. Biological evaluation found that 4, 5 and 6 are cytotoxic toward human cancer cells (A549, BGC-823, Kyse30) with IC50 values in the range of 63.43-80.83 ?M towards A549, 59.2 ± 2.73 ?M and 64.25 ± 0.37 ?M towards BGC-823, 76.28 ± 1.93 ?M and 85.42 ± 2.82 ?M towards Kyse30.

SUBMITTER: Yin YJ 

PROVIDER: S-EPMC6983046 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Meroterpenoids from the Fungus <i>Ganoderma sinensis</i> and First Absolute Configuration Clarification of Zizhine H.

Yin Yan-Jiao YJ   Huang Dan-Ling DL   Qiu Bin B   Cai Dan D   Zhang Jiao-Jiao JJ   Wang Shao-Xiang SX   Qin Da-Peng DP   Cheng Yong-Xian YX  

Molecules (Basel, Switzerland) 20191231 1


Five new meroterpenoids, zizhines P-S and U (<b>1</b>-<b>4</b>,<b>7</b>), together with two known meroterpenoids (<b>5</b> and <b>6</b>) were isolated from <i>Ganoderma sinensis</i>. Their structures including absolute configurations were assigned by using spectroscopic, computational, and chemical methods. Racemics zizhines P and Q were purified by HPLC on chiral phase. Biological evaluation found that <b>4</b>, <b>5</b> and <b>6</b> are cytotoxic toward human cancer cells (A549, BGC-823, Kyse3  ...[more]

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