Ontology highlight
ABSTRACT:
SUBMITTER: Frith TJ
PROVIDER: S-EPMC6101942 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Frith Thomas Jr TJ Granata Ilaria I Wind Matthew M Stout Erin E Thompson Oliver O Neumann Katrin K Stavish Dylan D Heath Paul R PR Ortmann Daniel D Hackland James Os JO Anastassiadis Konstantinos K Gouti Mina M Briscoe James J Wilson Valerie V Johnson Stuart L SL Placzek Marysia M Guarracino Mario R MR Andrews Peter W PW Tsakiridis Anestis A
eLife 20180810
The neural crest (NC) is a multipotent embryonic cell population that generates distinct cell types in an axial position-dependent manner. The production of NC cells from human pluripotent stem cells (hPSCs) is a valuable approach to study human NC biology. However, the origin of human trunk NC remains undefined and current in vitro differentiation strategies induce only a modest yield of trunk NC cells. Here we show that hPSC-derived axial progenitors, the posteriorly-located drivers of embryon ...[more]