Ontology highlight
ABSTRACT:
SUBMITTER: Carija A
PROVIDER: S-EPMC6101985 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Journal of visualized experiments : JoVE 20180623 136
Protein misfolding and aggregation into amyloid conformations have been related to the onset and progression of several neurodegenerative diseases. However, there is still little information about how insoluble protein aggregates exert their toxic effects in vivo. Simple prokaryotic and eukaryotic model organisms, such as bacteria and yeast, have contributed significantly to our present understanding of the mechanisms behind the intracellular amyloid formation, aggregates propagation, and toxici ...[more]