Ontology highlight
ABSTRACT:
SUBMITTER: Chen S
PROVIDER: S-EPMC6613214 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Chen Shi S Kapilashrami Kanishk K Senevirathne Chamara C Wang Zhen Z Wang Junyi J Linscott Joshua A JA Luo Minkui M
Journal of the American Chemical Society 20190514 20
Transition state stabilization is essential for rate acceleration of enzymatic reactions. Despite extensive studies on various transition state structures of enzymes, an intriguing puzzle is whether an enzyme can accommodate multiple transition states (TSs) to catalyze a chemical reaction. It is experimentally challenging to study this proposition in terms of the choices of suitable enzymes and the feasibility to distinguish multiple TSs. As a paradigm with the protein lysine methyltransferase ( ...[more]